The starting dose of Mounjaro is 2.5 mg once weekly. After 4 weeks, the dose should be increased to 5 mg once weekly. If necessary, the dose may be increased in 2.5 mg increments after a minimum of 4 weeks on the current dose.

The recommended maintenance doses are 5 mg, 10 mg and 15 mg.

The maximum dose is 15 mg once weekly.

When tirzepatide is added to existing metformin and/or sodium-glucose co-transporter 2 inhibitor (SGLT2i) therapy, the current dose of metformin and/or SGLT2i may be continued.

When Mounjaro is added to existing sulphonylurea and/or insulin therapy, a reduction in the dose of sulphonylurea or insulin may be considered to reduce the risk of hypoglycaemia. Self-monitoring of blood glucose is necessary to adjust the dose of sulfonylurea and insulin. A gradual approach to insulin reduction is recommended.

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